![]() ![]() DIM has multiple mechanisms of action, the most well-characterized is modulation of aryl hydrocarbon receptor (AHR) signaling. Recent clinical studies at Oregon State University show surprisingly robust metabolism of DIM in vivo with mono- and di-hydroxylation followed by conjugation with sulfate or glucuronic acid. The pharmacokinetics/pharmacodynamics of DIM have been studied in both rodents and humans and urinary DIM is a proposed biomarker of dietary intake of cruciferous vegetables. I3C and its major in vivo product, 3,3'-diindolylmethane (DIM), are effective cancer chemopreventive agents in pre-clinical models and show promise in clinical trials. Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles predominantly indole-3-carbinol (I3C). Department of Environmental and Molecular Toxicology, Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.Combined with a good safety track record, it makes a good ingredient for the Time Machine. It’s ability to control estradiol helps to counter estrogen dominance in men, and it raises testosterone indirectly. Indole-3-carbinol is also used for fibromyalgia, laryngeal papillomatosis caused by a virus, respiratory papillomatosis caused by a virus, cervical dysplasia, and systemic lupus erythematosus (SLE). The National Institutes of Health (NIH) has reviewed indole-3-carbinol as a possible cancer preventive agent and is now sponsoring clinical research for breast cancer prevention. Indole-3-carbinol is used for prevention of breast, colon, and other types of cancer. Indole-3-carbinol has been tested extensively and consistently exhibits strong antitumor activity via its regulation of estrogen activity and metabolism. The end effect is greater testosterone synthesis in the Leydig cells of the testes, as well as lower levels of estrogen and it’s associated effects. These events, however, are nullified by 2-hydroxy, which doesn’t provide the negative feedback message to the pituitary induced by estrogen. This leads to a unfavorable balance between testosterone and estrogen, testosteron being much lower. This means that high blood levels of estrogen, from aromatization of free testosterone, inhibit the release of LH from the pituitary gland. Estrogen creates a negative hormonal feedback loop to the pituitary gland, where the rate-limiting gonadotropin for testosterone synthesis, luteinizing hormone (LH) is synthesized and released. The 2-hydroxy estrogens promoted by usage also increase testosterone synthesis another way. Therefore these plasma binding proteins will latch on to 2-hydroxy, leaving greater levels of free testosterone in the blood The reason for this is that 2-hydroxy estrogens have a greater binding affinity for the blood proteins that bind with testosterone in the blood. Testosterone rises in the blood with use of diindolylmethane. This is quite desirable in the aging male body. Both are forms of estrogen, but when estriol binds to the estrogen receptors, the more powerful estradiol is blocked, and therefore cannot impart it’s strong “grow signals”. Indole 3 Carbinol helps to control the level of estradiol by converting it into the weaker form, estriol. Indole 3 Carbinol is converted by the digestive tract into diindolylmethane, which is then absorbed into the body. Indole 3 Carbinol is a dietary supplement that is derived from cruciferous vegetables such as broccoli, cabbage, cauliflower, brussels sprouts, collard greens and kale. ![]()
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