![]() Vegetables do not, in fact, contain indole-3-Carbinol. Glucobrassin is usually found in high concentrations in cabbage, Brussels sprouts, cauliflower, broccoli, kale, turnips, collards, and watercress (belonging to the cruciferous family of plants). How Can I Add Indole-3-Carbinol to my Diet? There is no known state of deficiency that exists with regards to the nutrient indole-3-carbinol. Do I Have a Deficiency of Indole-3-carbinol? These compounds are then absorbed by the body to create the therapeutic effect. Indole-3-carbinol appears to be metabolized into other compounds such as diindolylmethane (DIM), which is two IC3s bound together. It may also result in increased risk for heart disease, stroke, and estrogen-dependent cancers including ovarian and cervical cancer. An increase in estrogen may result in several gynecological conditions, such as bloating and tenderness of the breast during a woman’s menstrual cycle. Additionally, IC3 has shown to alter the metabolism or activity of the hormone estrogen in different ways, hindering the development of cancers that are estrogen-sensitive. Indole-3-carbinol is considered to be one of the most important phytochemicals that stimulates detoxification of the liver and the entire digestive tract. It also provides relief from symptoms of chronic fatigue syndrome and fibromyalgia, and may prevent or suppress the development of prostate, colon and breast cancers. Indole-3-carbinol plays a very important role, particularly in the elderly, when it comes to protecting the body against autoimmunity. It should also be noted that IC3 can modify the level of sex hormones, such as estrogens, contributing to both their anticancer activity and some of their side effects. In some experimental studies, it was suggested that IC3 can actually reduce oxidative stress by scavenging free radicals in your body, which further lowers our risk for certain types of cancers. Research shows that when given before or simultaneously with a carcinogen, IC3 has the ability to inhibit the development of cancers of the breast, uterus, colon, stomach, liver, prostate and lung. Chopping or chewing cruciferous vegetables releases the plant enzyme myrosinase, which breaks down glucobrassicin into indole-3-carbinol. ![]() Indole-3-carbinol, or IC3, is a product formed from the breakdown of glucobrassicin, a chemical compound that is naturally found in cruciferous vegetables, such as broccoli, cabbage, cauliflower, collard greens, kale, turnips and Brussels sprouts. ![]() This chapter summarizes the current experimental data on the I3C and DIM activity and the results of clinical studies indicating their role in prevention of chronic diseases.Īnimal models Chronic diseases DIM Dietary intervention trials Indole-3-carbinol Signaling pathways.Indole-3-carbinol (IC3) Fact Sheet About Indole-3-carbinol (IC3) Although most of the current data support the role of I3C and DIM in prevention of hormone-dependent cancers, it seems that their application in prevention of the other cancer as well as cardiovascular disease, obesity, and diabetes reduction is also possible. Now it is widely accepted that I3C and DIM affect multiple signaling pathways and target molecules controlling cell division, apoptosis, or angiogenesis deregulated in cancer cells. Initially, these compounds were classified as blocking agents that increase drug-metabolizing enzyme activity. Indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its condensation product, 3,3'-diindolylmethane (DIM) exert several biological activities on cellular and molecular levels, which contribute to their well-recognized chemoprevention potential. ![]()
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